The Blue Ridge Parkway crosses the North Carolina-Virginia state line at mile 216.9. The 1749 party that surveyed the boundary included Peter Jefferson, father of Thomas Jefferson.
- Mile 217.5 Cumberland Knob, at 2,885 feet (879 m), is the center piece of a small parkway recreation area.
- 218.6 Fox Hunters Paradise, down a short walking path, is where hunters could listen to their houndsbaying in the valley below.
- 238.5 Brinegar Cabin was built by Martin Brinegarabout 1880 and lived in until the 1930s when the homestead was purchased from his widow for the parkway. The original cabin stands there today.
- 238.5 to 244.7 Doughton Park was named for Congressman Robert L. Doughton, a staunch supporter and neighbor of the parkway. The park has many miles of hiking trails, a lodge, dinner, picnic area and a campground.
- 258.6 Northwest Trading Post offers crafts from North Carolina's northwestern counties.
- 260.6 Jumpinoff Rock is at the end of a short woodland trail.
- 264.4 The Lump is a grassy knob that provides views of the forested foothills.
- 272 E. B. Jeffress Park has a self-guided trail to a waterfall known as the Cascades. Another trail goes to an old cabin and church.
- 285.1 Daniel Boone's Trace, which Boone blazedto the West, crosses near here.
- 292 to 295 Moses H. Cone Memorial Park has hiking, fishing and horse trails. Flat Top Manor, the former house of Moses H. Cone, is now used as the Parkway Craft Center.
- 295.1 to 298 Julian Price Memorial Park, the former retreat of the insurance executive Julian Price, offers a variety of hiking trails, campground, and a 47-acre (190,000 m2) Price Lake. This is the only lake on the parkway on which paddling is allowed.
- 304.4 Linn Cove Viaduct, the last segment of the parkway built, skirts the side of Grandfather Mountain. A visitor center is located nearby and provides access to a trail under the viaduct.
- 308.3 Flat Rock provides views of Grandfather Mountain and Linville Valley.
- 316.3 Linville Falls Recreation Area provides trails with overlooks of Linville Falls and the Linville Gorge. A campground and picnic area are also provided.
- 331 Museum of North Carolina Minerals interprets the state's mineral wealth.
- 339.5 Crabtree Meadows & Crabtree Falls (North Carolina)is a parkway recreation area with a picnic area, campground, giftshop and hiking trails.
- 349.2 Laurel Knob, provides views of Grandfather Mountain, Linville Mountain, Hawksbill Mountain, and Table Rock (North Carolina).
- 355.4 Mount Mitchell State Park, reached via N.C. 128, is the highest point east of the Mississippi River.
- 359.8 Walker Knob, formerly known as Balsam Gap, is located where the Black Mountains (North Carolina) and the Great Craggy Mountains meet.
- 361.2 Glassmine Falls, an 800-foot (240 m) ephemeral waterfall visible from an overlook on the side of the parkway.
- 363.4 to 369.6 Craggy Gardens in the Great Craggy Mountains appear covered with purple rhododendron in mid-to-late June. Craggy Pinnacle Trail and other trails (364.1 and 364.6); road to picnic area and trails (367.6).
- 382 The Folk Art Center is the flagship facility of the Southern Highland Craft Guild. It offers sales and exhibits of traditional and contemporary crafts of the Appalachian region. There are interpretive programs, three galleries, a library and a book store.
- 384 The Blue Ridge Parkway Visitor Center is the newest attraction along the Parkway. The building itself is LEED- certified [1]. The Center houses a 70-seat theater showing an award-winning 24 minute film about the region. Information and orientation services are provided by the National Park Service and the Blue Ridge National Heritage Area. Eastern National has a retail shop offering books, apparel and more. There are several exhibits, including a 22-foot interactive map of the entire Blue Ridge Parkway known as the "I-Wall" which provides multi-media information on places to visit on and around the Parkway. Other exhibits focus on the history and heritage of the Parkway and Western North Carolina.
- 408.6 Mount Pisgah was part of the Biltmore Estate. The estate became home of the first forestry school in America and the nucleus of the Pisgah National Forest. Also located here is the Pisgah Inn resort, a park service concession.
- 417 Looking Glass Rock is visible from many spots on the Parkway starting at Mount Pisgah.
- 418 East Fork Overlook. Located here are the headwaters of the Pigeon River. Yellowstone Falls is a short distance away and gets its name from the yellowish moss covering the rocks.
- 420.2 Shining Rock Wilderness is the largest Wilderness in North Carolina with 18,483 acres (74.80 km2), 25 miles (40 km) of trails and peaks over 6,000 ft (1,800 m). The Wilderness is named for Shining Rock.
- 420.2 Black Balsam Knob is a grassy bald with panoramic views just outside of the Shining Rock Wilderness in Pisgah National Forest. The Wilderness also includes Cold Mountain.
- 422.4 Devil's Courthouse is a rugged exposed mountaintop rich in Cherokee traditions.
- 423.5 Herrin Knob Overlook. A hiking trail goes around Tanasee Bald and Herrin Knob. Tanasee Bald(423.7) is said to be the home of the mythical Cherokee giant Tsul 'Kalu.
- 431 Richland Balsam is the highest point on the parkway at 6,053 feet (1,845 m). There is a self-guiding trail that passes through a remnant spruce-firforest.
- 435.7 Licklog Ridge once hosted cattlemen and their herds of cattle before it became part of the national forest. The area earns its name from the cattlemen who would place rocks of salt into logs and holes in the earth.
- 451.2 Waterrock Knob provides a panorama of the Great Smokies, visitor center, trail, comfort station, exhibits.
- 458.2 Heintooga Overlook spur road goes to a mile-high overlook 1.3 miles (2.1 km) from the parkway.
- Mile 469 Southern End of the Blue Ridge Parkway intersects with U.S. 441 in the Great Smoky Mountains National Park and the Cherokee Reservation near Cherokee, North Carolina.
